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KMID : 1101220030350010057
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2003 Volume.35 No. 1 p.57 ~ p.67
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Correlations Between the Expression of Steroid Hormone Receptors and Oncoproteins as a Histologic Grade of Breast Cancer
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Kim Tai-Jeon
Moon Hi-Joo
Bae Hyung-Joon
Back Oun-Chul
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Abstract
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This study was designed to compare and analyze the overall relationship between independent factors inducing breast cancer, the steroid hormone receptors(ER and PR), and oncoproteins(C-erbB-2, P-53 and Bcl-2). A total of 21 test samples underwent tissue studies with H&E staining to test histologic grading. ER, PR, P-53, C-erbB-2, Bcl-2, and Ki 67 were examined with immunohistochemistry. Although ER and PR showed no statistically significant difference in histologic grade, the induction of PR increased when induction of ER increased showing a significant relationship(P<0.05). C-erbB-2 oncoprotein showed no statistically significant relationship with histologic grade, nuclei mitosis index, lymphnode metastasis, menopause, and P-53 oncoprotein, whereas it showed a statistically significant relationship with PR, ER, and Bcl-2 oncoproteins(P<0.05). P-53 oncoprotein showed no statistically significant relationship with C-erbB-2 oncoprotein, histologic grade, lymphnode metastasis, and menopause, whereas it showed statistically significant relationships with ER, PR, Bcl-2, and nuclei mitosis index(P<0.05). Bcl-2 oncoprotein showed no statistically significant relationship with lymphnode metastasis, histologic grade, and menopause, whereas it showed statistically significant relationships with other pathological prognosis factors(ER, PR, P-53, C-erbB-2 and nuclei mitosis index)(P<0.05). In conclusion, ER, PR, and oncoproteins(C-erbB-2, P-53 and Bcl-2) showed no significant difference with histologic grade. However ER, PR, and oncoproteins showed significant relationships with each other. The induction rate of P-53 oncoprotein was low when that of Bcl-2 oncoprotein was high while Bcl-2 oncoprotein and P-53 oncoprotein showed a reciprocal relationship with each other.
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KEYWORD
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Steroid hormone receptors(ER and PR), Oncoproteins(P-53, C-erbB-2 and Bcl-2), Histologic grade
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